An Integrated Approach for RNA-seq Data Normalization
نویسندگان
چکیده
منابع مشابه
An Integrated Approach for RNA-seq Data Normalization
BACKGROUND DNA copy number alteration is common in many cancers. Studies have shown that insertion or deletion of DNA sequences can directly alter gene expression, and significant correlation exists between DNA copy number and gene expression. Data normalization is a critical step in the analysis of gene expression generated by RNA-seq technology. Successful normalization reduces/removes unwant...
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RNA-sequencing (RNA-Seq) has become the technology of choice for whole-transcriptome profiling. However, processing the millions of sequence reads generated requires considerable bioinformatics skills and computational resources. At each step of the processing pipeline many tools are available, each with specific advantages and disadvantages. While using a specific combination of tools might be...
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ژورنال
عنوان ژورنال: Cancer Informatics
سال: 2016
ISSN: 1176-9351,1176-9351
DOI: 10.4137/cin.s39781